Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease

Figure 2

The 3 h totals of abnormal involuntary movement (AIM) scores on treatment Days 1, 8, and 15 in the apomorphine only group, apomorphine plus zonisamide group, and zonisamide only group. AIM scores are shown for four subtypes: locomotive dyskinesia (a), axial dystonia (b), limb dyskinesia (c), and orolingual dyskinesia (d), and for the total score of axial dystonia, limb dyskinesia, and orolingual dyskinesia (ALO AIM) (e). There were no significant differences between the apomorphine only group and apomorphine plus zonisamide group. Diamonds indicate the scores of the apomorphine only group, squares indicate the scores of the apomorphine plus zonisamide group, and triangles indicate the scores of the zonisamide only group. Data are expressed as mean ± standard deviation. NS, not significant.

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