Zonisamide Enhances Motor Effects of Levodopa, Not of Apomorphine, in a Rat Model of Parkinson’s Disease

Figure 4

Abnormal involuntary movement (AIM) scores at each time point after drug injection on treatment Day 15 in the apomorphine only group and the apomorphine plus zonisamide group. AIM scores are shown for four subtypes: locomotive dyskinesia (a), axial dystonia (b), limb dyskinesia (c), and orolingual dyskinesia (d), and for the total score of axial dystonia, limb dyskinesia, and orolingual dyskinesia (ALO AIM) (e). There were no significant differences between the groups. Diamonds indicate the scores of the apomorphine only group and squares indicate the scores of the apomorphine plus zonisamide group. Data are expressed as mean ± standard deviation. NS, not significant.

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