Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson’s Disease Patients

Table 3

Linear regression analysis of factors influencing patient health-related quality of life (PDQ-8), n = 124.

Variables	R^2	Beta
Age	0.0262	0.162	0.074
Disease duration	0.1005	0.315	<0.001
MDS-UPDRS total	0.2209	0.472	<0.001
MDS-UPDRS part I	0.1910	0.478	<0.001
MDS-UPDRS part II	0.1892	0.440	<0.001
MDS-UPDRS part III	0.0999	0.319	<0.001
MDS-UPDRS part IV	0.0936	0.306	0.001
MoCA	0.0566	−0.240	0.008
MoCA-EIS	0.0882	−0.296	0.001
MoCA-VIS	0.0784	−0.247	0.006
MoCA-AIS	0.1282	−0.260	<0.001
MoCA-OIS	0.0562	−0.220	0.016
MoCA-MIS	0.0119	−0.110	0.231
MoCA-LIS	0.0106	−0.101	0.270
BDI	0.2089	0.445	<0.001

Linear regression analysis of factors contributing to patients’ health-related quality of life. value adjustment for multiple comparisons was 0.05/15. Significant correlations at ; Significance level at printed in bold. BDI, Beck Depression Inventory; MDS-UPDRS, Movement Disorders Society unified Parkinson’s disease rating scale; MoCA, Montreal cognitive assessment scale; EIS, executive index score; VIS, visual index score; AIS, attention index score; OIS, orientation index score; MIS, memory index score; LIS, language index score; PDQ-8, Parkinson’s disease questionnaire 8.