Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson’s Disease Patients

Table 4

Linear regression analysis of factors influencing caregiver burden (PDCB), n = 78.

Variables	R^2	Beta
PD patient BDI	0.0292	0.165	0.229
MDS-UPDRS part I	0.0812	0.287	0.012
MDS-UPDRS part II	0.0818	0.282	0.014
MDS-UPDRS part III	0.2070	0.433	<0.001
MDS-UPDRS part IV	0.0467	0.219	0.058
MoCA	0.0625	−0.254	0.029
MoCA-EIS	0.0524	−0.222	0.057
MoCA-VIS	0.0480	−0.176	0.134
MoCA-AIS	0.1815	−0.417	<0.001
MoCA-OIS	0.0110	−0.098	0.405
MoCA-MIS	0.0445	−0.212	0.070
MoCA-LIS	0.0818	−0.284	0.014
PDQ-8	0.1840	0.436	<0.001
CG-SF-36 total	0.0243	−0.157	0.193
CG-h/d	0.1069	0.305	0.037
CG-BDI	0.1560	0.402	<0.001

value adjustment for multiple comparisons was 0.05/16. Significant correlations at ; significance level at . BDI, Beck Depression Inventory; CG, caregiver; MDS-UPDRS, Movement Disorders Society-unified Parkinson’s disease rating scale; MoCA, Montreal cognitive assessment scale; EIS, executive index score; VIS, visual index score; AIS, attention index score; OIS, orientation index score; MIS, memory index score; LIS, language index score; PDCB Parkinson’s disease caregiver burden inventory; PDQ-8, Parkinson’s disease questionnaire 8; and SF-36, short form 36 health survey.