CUB and Sushi Multiple Domains (CSMD1) Gene Polymorphisms and Susceptibilities to Idiopathic Parkinson’s Disease in Northern Chinese Han Population: A Case-Control Study
Table 3
Distributions of genotypes and alleles at rs12681349, rs10503253, and rs1983474 among Chinese with PD patients and healthy controls.
SNP
PD (%)
Control (%)
OR (95% CI)
rs12681349 (C＞T)
Genotype frequency
CC
309 (73.0)
351 (75.5)
—
—
CT
99 (23.4)
101 (21.7)
0.537
0.905 (0.659–1.243)
TT
15 (3.5)
13 (2.8)
0.493
0.767 (0.359–1.638)
Allele frequency
C
717 (84.8)
803 (86.3)
—
—
T
129 (15.2)
127 (13.7)
0.340
0.879 (0.674–1.146)
Dominant model
TT + CT
114 (27.0)
114 (24.5)
—
—
CC
309 (73.0)
351 (75.5)
0.435
1.128 (0.834–1.525)
Recessive model
TT
15 (3.5)
13 (2.8)
—
—
CC + CT
408 (96.5)
452 (97.2)
0.530
1.274 (0.598–2.713)
HWE
—
—
—
rs10503253 (C＞A)
Genotype frequency
CC
268 (63.4)
251 (54.0)
—
—
CA
127 (30.0)
184 (39.6)
0.002
1.554 (1.169–2.066)
AA
28 (6.6)
30 (6.5)
0.649
1.135 (0.658–1.957)
Allele frequency
A
183 (21.6)
244 (26.2)
—
—
C
663 (78.4)
686 (73.8)
0.046
0.776 (0.623–0.996)
Dominant model
AA + CA
155 (36.6)
214 (46.0)
—
—
CC
268 (63.4)
251 (54.0)
0.004
0.677 (0.517–0.886)
Recessive model
AA
28 (6.6)
30 (6.5)
—
—
CC + CA
395 (93.4)
435 (93.5)
0.897
1.036 (0.607–1.768)
HWE
—
—
—
rs1983474 (T＞G)
Genotype frequency
TT
134 (31.7)
152 (32.7)
—
—
TG
197 (46.6)
245 (52.7)
0.311
1.170 (0.864–1.584)
GG
92 (21.7)
68 (14.6)
0.012
0.599 (0.401–0.895)
Allele frequency
T
465 (55.0)
549 (59.0)
—
—
G
381 (45.0)
381 (41.0)
0.084
0.847 (0.702–1.022)
Dominant model
GG + TG
289 (68.3)
313 (67.3)
—
—
TT
134 (31.7)
152 (32.7)
0.914
1.016 (0.763–1.353)
Recessive model
GG
92 (21.7)
68 (14.6)
—
—
TT + TG
331 (78.3)
397 (85.4)
0.001
1.837 (1.287–2.620)
HWE
—
—
—
SNP: single nucleotide polymorphisms; HWE: Hardy–Weinberg equilibrium; OR: odds ratio; 95% CI: 95% confidence interval; CI: confidence interval; was statistically significant, which is given in bold.
