CUB and Sushi Multiple Domains (CSMD1) Gene Polymorphisms and Susceptibilities to Idiopathic Parkinson’s Disease in Northern Chinese Han Population: A Case-Control Study
Table 5
Distributions of rs10503253 polymorphism in different subcomponent types.
rs10503253
Genotype
PD (%)
Control (%)
OR (95% CI)
Male
CC
139 (62.1)
137 (55.7)
—
—
CA
66 (29.5)
90 (36.6)
0.090
1.480 (0.941–2.326)
AA
19 (8.5)
19 (7.7)
0.169
0.615 (0.307–1.230)
C
344 (76.8)
364 (74.0)
—
—
A
104 (23.2)
128 (26.0)
0.320
1.163 (0.864–1.567)
Female
CC
129 (64.8)
114 (52.1)
—
—
CA
61 (30.7)
94 (42.9)
0.008
1.740 (1.156–2.620)
AA
9 (4.5)
11 (5.0)
0.472
1.400 (0.560–3.505)
A
79 (19.8)
116 (26.5)
—
—
C
319 (80.2)
322 (73.5)
0.023
0.687 (0.497–0.952)
EOPD
CC
25 (59.5)
36 (53.7)
—
—
CA
13 (31.0)
26 (38.8)
0.507
1.335 (0.568–3.139)
AA
4 (9.5)
5 (7.5)
0.930
0.935 (0.213–4.116)
C
63 (75.0)
98 (73.1)
—
—
A
21 (25.0)
36 (26.9)
0.760
1.102 (0.590–2.058)
LOPD
CC
242 (63.8)
215 (54.0)
—
—
CA
114 (29.9)
158 (39.7)
0.004
1.570 (1.159–2.126)
AA
24 (6.3)
25 (6.3)
0.594
1.174 (0.651–2.117)
A
162 (21.3)
208 (26.1)
—
—
C
598 (78.7)
588 (73.9)
0.026
0.766 (0.606–0.969)
EOPD: early-onset Parkinson’s disease; LOPD: late-onset Parkinson’s disease; OR: odds ratio; CI: confidence interval; was statistically significant, which is given in bold.
