CUB and Sushi Multiple Domains (CSMD1) Gene Polymorphisms and Susceptibilities to Idiopathic Parkinson’s Disease in Northern Chinese Han Population: A Case-Control Study
Table 8
Results of false-positive report probability analysis for significant findings.
Genotype and variables
OR (95% CI)
value
Statistical powera
Prior probability
0.25
0.1
0.01
0.001
0.0001
rs10503253 (C＞A)
CA versus CC
1.554 (1.169–2.066)
0.002
0.995
0.018
0.051b
0.372
0.857
0.984
C versus A
0.776 (0.623–0.996)
0.046
0.390
0.136
0.321
0.839
0.981
0.998
CC versus AA + CA
0.677 (0.517–0.886)
0.004
0.795
0.024
0.069b
0.449
0.892
0.988
CA versus CC
Female
1.740 (1.156–2.620)
0.008
0.859
0.091
0.232
0.768
0.971
0.997
LOPD
1.570 (1.159–2.126)
0.004
0.915
0.027
0.077b
0.477
0.902
0.989
C versus A
Female
0.687 (0.497–0.952)
0.023
0.405
0.112
0.275
0.807
0.977
0.998
LOPD
0.766 (0.606–0.969)
0.026
0.380
0.082
0.212
0.748
0.968
0.997
rs1983474 (T＞G)
GG versus TT
0.599 (0.401–0.895)
0.012
0.603
0.110
0.270
0.803
0.976
0.998
TT + TG versus GG
1.837 (1.287–2.620)
0.001
0.822
0.018
0.051
0.372
0.857
0.984
TG versus TT
Male
2.160 (1.162–4.016)
0.015
0.985
0.265
0.519
0.922
0.992
0.999
rs1983474 (T＞G)
GG versus TT
0.599 (0.401–0.895)
0.012
0.603
0.110
0.270
0.803
0.976
0.998
TT + TG versus GG
1.837 (1.287–2.620)
0.001
0.822
0.018
0.051
0.372
0.857
0.984
TG versus TT
Male
2.160 (1.162–4.016)
0.015
0.985
0.265
0.519
0.922
0.992
0.999
EOPD
0.358 (0.150–0.855)
0.021
0.480
0.435
0.698
0.962
0.996
1.000
LOPD
1.393 (1.004–1.934)
0.047
0.658
0.176
0.390
0.876
0.986
0.999
GG versus TT
Female
0.418 (0.234–0.746)
0.003
0.561
0.142
0.333
0.846
0.982
0.998
LOPD
0.643 (0.420–0.985)
0.042
0.459
0.227
0.468
0.906
0.990
0.999
T versus G
Female
1.471 (1.118–1.935)
0.006
0.535
0.030
0.086
0.508
0.912
0.991
OR: odds ratio; CI: confidence interval. aStatistical powers were calculated using the number of observations in the subgroup and the OR and values. “b” denotes noteworthy findings are highlighted.
