Review Article
Cognitive Impairment in Genetic Parkinson’s Disease
Table 2
Studies assessing cognitive function in Parkin-associated PD.
| | | Participants | Type of study | Cognitive measures | Findings |
| | Luking et al. [61] | 101 Parkin-EOPD (≤45 years) | Cross-sectional | MMSE | No significant differences | | 85 EOPD noncarriers | | Alcalay et al. [64] | 43 Parkin-EOPD (≤50 years) | Cross-sectional | MMSE | No significant differences | | 596 LRRK2-EOPD, GBA-EOPD, and noncarriers | | Lohmann et al. [65] | 21 Parkin-EOPD (<45 years) | Cross-sectional | MMSE, MDRS, Grober and Buschke test, WCST, TMT, FAB | No significant differences | | 23 EOPD noncarriers | | 9 asymptomatic Parkin carriers | | Caccappolo et al. [66] | 43 Parkin-EOPD (≤50 years) | Cross-sectional | Neuropsychological battery | No significant differences | | 52 EOPD noncarriers | | 217 controls (146 noncarriers and 71 asymptomatic Parkin carriers) | | CORE-PD cohort | | Alcalay et al. [67] | 21 Parkin-EOPD (≤50 years) and long duration disease (>14 years) | Cross-sectional | Neuropsychological battery | Parkin-PD performed better on tests of attention, memory, and visuospatial cognitive domains | | 23 EOPD noncarriers | | CORE-PD cohort | | Tan et al. [33] | 9 Parkin-EOPD (≤50 years) | Cross-sectional | MoCA | Parkin-PD performed better | | 202 EOPD noncarriers |
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EOPD = early-onset Parkinson’s disease; MMSE = Mini-Mental State Examination; MDRS = Mattis Dementia Rating Scale; WCST = Wisconsin card sorting test; TMT = trail-making test; FAB = frontal assessment battery.
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