Efficacy and Safety of Pramipexole Sustained Release versus Immediate Release Formulation for Nocturnal Symptoms in Chinese Patients with Advanced Parkinson’s Disease: A Pilot Study

Figure 2

Adjusted mean changes from baseline in PDSS-2 over time in titration/maintenance period (FAS). Adjusted with factors treatment, titration/maintenance period, and covariate baseline. The current trend is consistent with the planned primary analysis for mean changes from baseline in PDSS-2 over time, which adjusted with factors treatment, maintenance phase and covariate baseline. Unstructured covariance matrix, Kenward–Roger approximation for denominator degrees of freedom. FAS, full analysis set; IR, immediate release; PDSS-2, Parkinson’s Disease Sleep Scale 2^nd version; PPX, pramipexole; SE, standard error; SR, sustained release.