| | GLA variant | Origin | Family history | Age | Gender | Age of onset | PD subtype | Falls | Freezing | Tremor | MDS-UPDRS part III ON | HY stage | Motor fluctuations | NMS | Cognition | Initial motor features | Prodromal features | Current medication |
| | p.(Asp313Tyr) | Slovak (ES) | − | 68 | F | 56 | PIGD | + | + | − | 35 | 4 | Wearing off, PoD dyskin | Insomnia, fatigue, daytime sleepiness, frequent Urination, nocturia, constipation, depression, apathy, anxious mood, vertigo-dizziness, | MoCA 29/30, PD-CRS
99/134 | Balance problems, left-side bradykinesia, and rigidity | Smell loss, sweating | LCIG 4,2 ml/per hour | | p.(Asp313Tyr) | Slovak (VA) | − | 66 | F | 61 | Mixed | − | − | + | 13 | 1 | PoD dyskinesia, wearing off | Urine urgency, nykturia, fatigue, mild anxious mood, mild hyposmia | MoCA 27/30, PD-CRS 94/134 | Pain and tremor of the left hand | Fatigue, constipation, sweating, urine urgency, anxiety | L/C 200 mg/D | | p.(Asp313Tyr) | Slovak (AS) | − | 75 | F | 69 | Mixed | − | + | − | 20 | 2 | PoD dyskinesia | Daytime sleepiness, fatigue, urine urgency | MoCA 25/30, PD-CRS
62/134 | Tremor of the right hand | Smell loss, excessive sweating | L/C 875 mg/D
PPX 1,57
mg/D | | p.(Asp313Tyr) | Slovak (HR) | − | 70 | F | 60 | Mixed | − | + | + | 32 | 2 | PoD dyskinesia,
wearing off | Urine urgency, depression, anxious mood, chronic pain of lower limbs | MoCA 21/30 | Tremor of the right hand | Sweating, urine urgency | L/C 500 mg/D
rasagilin 1 mg/D |
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Y, years; PD, Parkinson’s disease; MDS-UPDRS, Movement Disorder Society-Unified Parkinson’s Disease Rating Scale; HY, Hoehn and Yahr; NMS, nonmotor symptoms; F, female; M, male; PIGD, postural instability gait disorder; PoD, peak-of-dose; MoCA, Montreal Cognitive Assessment; L/C, levodopa/carbidopa; PPX, pramipexole; PD-CRS, and Parkinson’s disease cognitive rating scale.
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