DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce <i>α</i>-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model

<div>Apomorphine-induced circling and histology of the SN. Animals received apomorphine i.p. (0.05 mg/kg body weight). After 10 min of injection, the rats were placed in an open-field arena, and their activity was recorded for 30 min. (a) Contralateral turns of apomorphine-induced rotation (means and SEM shown, <i>N</i> = 10 per group; one-way ANOVA followed by Tukey comparisons test). (b) Quantification of TH labeling in the SNpc. 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<i>N</i> = 6 per group. (c) Representative fluorescence microscopy images of TH staining in the substantia nigra (scale bar = 50 <i>μ</i>m). Top left panel: Sham control; top right panel: 6-OHDA + Sal; lower left panel: 6-OHDA + Sema; lower right panel: 6-OHDA + DA5-CH.</div>

Parkinson’s Disease

fig2

Figure 2

Figure 2: DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce <i>α</i>-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model 

Parkinson’s Disease

DA5-CH and Semaglutide Protect against Neurodegeneration and Reduce α-Synuclein Levels in the 6-OHDA Parkinson’s Disease Rat Model

Figure 2