MAO-B Polymorphism Associated with Progression in a Chinese Parkinson’s Disease Cohort but Not in the PPMI Cohort

Table 4

Association between haplotypes and progression in the TW and PPMI cohorts.

Cohort	HaploBlock	Haplotype	Prog	Estimate (95% CI)	value
PPMI	PARK16 haplotype	ACAG	GDS	6375 (3028–9721)	0.0002068
		ACCA	GDS	6375 (3028–9721)	0.0002068
		ATCA	GDS	6375 (3028–9721)	0.0002068
		GCCA	GDS	6375 (3028–9721)	0.0002068
		GCAG	GDS	6375 (3028–9721)	0.0002069
		GTCA	GDS	6719 (3192–10247)	0.0002070
		ATCG	GDS	6375 (3028–9721)	0.0002068
		ACCG	GDS	430472 (204429–656514)	0.0002077
		ACAG	STAI	42709 (17981–67436)	0.0007535
		ACCA	STAI	42709 (17982–67437)	0.0007534
		ATCA	STAI	42709 (17982–67436)	0.0007534
		GCCA	STAI	42708 (17981–67435)	0.0007534
		GCAG	STAI	42711 (17983–67438)	0.0007531
		GTCA	STAI	45020 (18954–71085)	0.0007534
		ATCG	STAI	42709 (17982–67436)	0.0007534
		ACCG	STAI	2884040 (1213734–4554345)	0.0007563
	SNCA haplotype	AGTGCA	Hoehn-Yahr staging	255 (161–348)	<0.000001
PPMI	SNCA haplotype	AGTGCA	Motor PC1	−3090 (-4978–1201)	0.0014101

GDS, geriatric depression scale; PC, principal component; STAI, state-trait anxiety inventory for adults.