Functional MAOB Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson’s Disease

Figure 2

Risk of levodopa-induced motor complications with respect to genotypes in the MAOB rs1799836 polymorphism. Kaplan–Meier curves show the association between MAOB rs1799836 genotypes (MAOB^CC/(C)/CT genotypes: associated with low/intermediate enzyme activity in the brain (blue line); MAOB^TT/(T) genotypes: associated with high enzyme activity in the brain (green line)) and the risk for wearing-off (a), levodopa-induced dyskinesia (b), and any motor complication (c). Hazard ratios (HR) with 95% confidence intervals (95% CI) and values are from univariate Cox proportional hazard models with those genotypes associated with high MAOB activity (MAOB^TT/(T)) adopted as the reference group.

(a)

(b)

(c)