Parkinson’s Disease

Research Article

Functional MAOB Gene Intron 13 Polymorphism Predicts Dyskinesia in Parkinson’s Disease

Table 1

Cox proportional hazard ratios estimating the risk for motor complications with respect to genotypes in functional polymorphisms associated with lower enzyme/transporter activity^a.


	Wearing-off				Levodopa-induced dyskinesia				Any motor complication
	HR (95% CI)^b		Adjusted HR (95% CI)^b,c		HR (95% CI)^b		Adjusted HR (95% CI)^b,c		HR (95% CI)^b,c

DDC^CC/CT (rs921451)	0.569 (0.218–1.488)	0.250	0.633 (0.240–1.668)	0.355	0.699 (0.218–2.244)	0.548	0.801 (0.237–2.705)	0.721	0.514 (0.196–1.350)	0.177
MAOB^CC/(C)/CT (rs1799836)	0.566 (0.242–1.322)	0.189	0.197 (0.563–1.347)	0.197	0.264 (0.089–0.787)	0.012	0.142 (0.039–0.520)	0.003	0.554 (0.235–1.304)	0.176
COMT^AA/AG (rs4680)	1.216 (0.410–3.607)	0.725	1.277 (0.430–3.789)	0.660	5.526 (0.725–42.095)	0.099	5.298 (0.677–41.484)	0.112	1.280 (0.432–3.795)	0.656
DAT^≤9/≤10 (VNTR)	0.869 (0.370–2.039)	0.746	1.081 (0.452–2.582)	0.861	0.943 (0.335–2.655)	0.912	1.108 (0.372–3.295)	0.854	0.994 (0.422–2.338)	0.988

HR: hazard ratio; 95% CI: 95% confidence interval. ^aPatients were grouped into low/intermediate enzyme/transporter activity (DDC^CC/CT (n = 23); MAOB^CC/(C)/CT (n = 16); COMT^AA/AG (n = 23); DAT^≤9/≤10 (n = 13)) and high enzyme/transporter activity (DDC^TT (n = 7); MAOB^TT/(T) (n = 14); COMT^GG (n = 7); DAT^10/10 (n = 17)). Refer to Supplementary Table S1 for details. ^bAn HR < 1 indicates smaller risk for motor complications with genotypes resulting in low/intermediate enzyme/transporter activity (DDC^CC/CT rs921451 genotype; MAOB^CC/(C)/CT rs1799836 genotype; COMT^AA/AG rs4680 genotype; DAT^≤9/≤10 V NTR genotype). ^cAdjustment of HR for relevant covariates was performed by using multivariate Cox proportional hazard models using a stepwise selection process retaining as final variables disease duration at baseline for the prediction of wearing-off, gender, disease duration at baseline, and MAOB-I therapy for levodopa-induced dyskinesia and no variables for any motor complication (no adjustment needed).