Diagnostic Test to Identify Parkinson’s Disease from the Blood Sera of Chinese Population: A Cross-Sectional Study
Table 2
Differential exosomal microRNA (miRNA) expression in serum and cerebrospinal fluid (CSF) samples of Parkinson’s disease (PD), neurodegenerative disorder (ND), and control subjects.
miRNA member
Serum
miRNA member
CSF
PD VS control
PD VS ND
PD VS control
PD VS ND
hsa-mirName
FC (log2)
Adjusted value
FC (log2)
Adjusted value
has-mirName
FC (log2)
Adjusted value
Fold change (log2)
Adjusted value
Up + 17
Dn- = 10
Up + 19
Dn- = 8
hsa-miR-151a-5p
1.37
0.0042
0.74
0.313
hsa-miR-151a-5p
1.31
0.0073
0.51
0.035
hsa-miR-24
2.31
0.0074
−0.96
0.131
hsa-miR-24
1.62
0.0028
−0.19
0.173
hsa-miR-485-5p
1.95
0.0032
−0.78
0.061
hsa-mir-485-5p
1.79
0.0087
−0.56
0.169
hsa-miR-331-5p
1.63
0.0024
−0.27
0.042
hsa-mir-331-5p
1.43
0.0067
1.34
0.231
hsa-mir-214
1.45
0.0064
0.85
0.067
hsa-mir-214
2.18
0.0013
0.37
0.052
hsa-miR-29b-2-5p
−1.56
0.0086
−0.63
0.008
hsa-mir-1
−0.75
0.0043
0.63
0.042
hsa-miR-29c
1.43
0.0053
0.74
0.045
hsa-let-7b
1.23
0.0023
0.72
0.013
hsa-miR-16-2-3p
2.04
0.0042
−0.24
0.141
hsa-let-7f-1-3p
0.84
0.0075
0.13
0.143
hsa-let-7d-5p
−1.42
0.0065
0.68
0.042
hsa-mir-103a
−0.64
0.0054
−0.63
0.125
hsa-miR-200a
1.43
0.0021
−0.24
0.214
hsa-mir-127-3p
1.62
0.0022
0.76
0.315
hsa-miR-126
1.39
0.0089
0.34
0.061
hsa-mir-136-3p
−0.63
0.0095
−0.28
0.531
hsa- miR-221
0. 91
0.0024
−0.15
0.162
hsa-mir-151
1.56
0.0044
−0.47
0.173
hsa- miR-148b
−0.76
0.0086
0.85
0.341
hsa-mir-153
−0.72
0.0093
−0.63
0.251
hsa- miR-19a
1.02
0.0086
−0.46
0.142
hsa-miR-16
1.53
0.0031
−0.71
0.152
hsa-miR-29b
−0.84
0.0032
0.09
0.041
hsa-mir-16-2
1.46
0.0064
0.08
0.173
hsa-miR-126a
2.46
0.0065
−0.85
0.085
hsa-miR-200a-3p
1.08
0.0046
0.38
0.663
hsa-miR-151-5p
−0.82
0.0087
0.47
0.231
hsa-miR-200a-5p
2.42
0.0043
−0.21
0.113
hsa- miR-24
1.18
0.0079
−0.41
0.062
hsa-mir-22
2.31
0.0015
−0.52
0.085
hsa-miR-374a
−0.73
0.0067
0.65
0.184
hsa-mir-26a
−1.35
0.0065
−0.63
0.352
hsa-miR-15b
−0.16
0.0096
0.54
0.042
hsa-miR-26a-5p
1.86
0.0032
0.82
0.374
hsa-let-7a
0.66
0.0041
−0.96
0.139
hsa-mir-29
1.24
0.0065
0.48
0.139
hsa-miR-29a-3p
−0.43
0.0085
0.85
0.045
hsa-miR-29b-1
1.21
0.0028
−0.46
0.421
hsa- miR-626
−0.84
0.0069
0.52
0.101
hsa-mir-30b
0.84
0.0054
−0.51
0.732
hsa-miR-301a
2.71
0.0022
0.55
0.126
hsa-miR-331-3p
−0.72
0.0025
−0.52
0.024
hsa-miR-28-5p
1.31
0.0046
−0.71
0.272
hsa-mir-374
2.04
0.0026
1.06
0.214
hsa-miR-1
−0.34
0.0085
0.87
0.168
hsa-mir-409-3p
−1.12
0.0086
−0.09
0.118
hsa- miR-29c
0.96
0.0053
1.39
0.172
hsa-miR-485-3p
−0.44
0.0034
0.87
0.031
VS = versus; FC = fold change; Dn Downregulated; hsa-miR = human miRNA; PD = Parkinson’s disease; ND = neurodegenerative disease.
