Association between Cognitive Impairment and Hippocampal Subfield Volumes in Multiple System Atrophy

Table 2

Group comparison of hippocampal subfield volume.

	MSA-CI	MSA-CP	HC	F value	Partial eta^2	value
	n = 40	n = 35	n = 68			MSA-CI vs. MSA-CP	MSA-CI vs. HC	MSA-CP vs. HC
Left hippocampal tail	521.2 ± 68.4	565.4 ± 61.4	531.8 ± 67.2	1.504	0.022	0.294	1.000	0.534
Left subiculum	426.0 ± 67.6	447.5 ± 45.0	433.4 ± 50.2	0.067	0.001	1.000	1.000	1.000
Left CA1	580.0 ± 84.6	626.6 ± 77.9	603.4 ± 80.2	2.285	0.033	0.139	0.254	1.000
Left hippocampal fissure	166.7 ± 30.2	167.7 ± 30.2	160.1 ± 34.5	1.278	0.018	0.357	1.000	0.753
Left presubiculum	320.7 ± 50.3	322.9 ± 41.9	321.0 ± 46.4	0.131	0.002	1.000	1.000	1.000
Left parasubiculum	65.4 ± 19.2	62.9 ± 15.8	63.8 ± 17.4	0.146	0.002	1.000	1.000	1.000
Left molecular layer	513.0 ± 73.3	549.1 ± 49.2	531.0 ± 61.1	1.278	0.018	0.491	0.467	1.000
Left GC-ML-DG	262.1 ± 39.3	278.6 ± 23.9	271.0 ± 35.2	1.641	0.024	0.659	0.226	1.000
Left CA2/3	192.6 ± 32.6	199.5 ± 23.4	196.3 ± 28.8	1.758	0.025	0.548	0.204	1.000
Left CA4	229.0 ± 33.6	238.4 ± 20.8	234.2 ± 29.2	1.209	0.017	1.000	0.373	1.000
Left fimbria	63.5 ± 30.7	83.0 ± 27.1	64.6 ± 20.1	3.139	0.044	0.965	0.553	0.046
Left HATA	52.0 ± 8.5	56.0 ± 7.9	53.5 ± 8.8	2.111	0.030	0.164	0.298	1.000
Left whole hippocampus	3225.6 ± 417.0	3429.9 ± 281.6	3304.1 ± 334.4	1.289	0.019	0.381	0.634	1.000
Right hippocampal tail	560.7 ± 86.8	598.2 ± 64.5	559.2 ± 71.4	0.742	0.011	0.865	1.000	0.824
Right subiculum	436.9 ± 60.0	462.9 ± 45.2	437.4 ± 53.4	1.146	0.017	0.651	1.000	0.471
Right CA1	634.0 ± 79.2	684.4 ± 84.4	644.2 ± 82.3	1.673	0.024	0.212	1.000	0.708
Right hippocampal fissure	194.9 ± 38.4	180.5 ± 35.4	169.5 ± 37.5	1.154	0.017	1.000	0.695	0.597
Right presubiculum	298.2 ± 47.9	312.0 ± 39.1	307.2 ± 41.0	0.588	0.009	1.000	0.849	1.000
Right parasubiculum	53.9 ± 16.7	55.1 ± 14.7	55.4 ± 13.3	0.730	0.011	1.000	0.754	1.000
Right molecular layer	537.3 ± 66.6	581.4 ± 54.4	552.8 ± 59.8	2.570	0.036	0.080	0.365	0.957
Right GC-ML-DG	273.7 ± 36.0	293.1 ± 29.6	282.6 ± 35.6	2.943	0.041	0.123	0.085	1.000
Right CA2/3	209.8 ± 32.5	218.5 ± 26.8	215.6 ± 30.1	3.673	0.051	0.125	0.029	1.000
Right CA4	239.4 ± 31.2	251.4 ± 26.0	244.1 ± 30.0	2.616	0.037	0.170	0.110	1.000
Right fimbria	58.0 ± 24.9	81.2 ± 30.2	62.9 ± 21.1	2.858	0.040	0.429	1.000	0.055
Right HATA	53.4 ± 8.7	58.5 ± 12.0	57.2 ± 10.1	1.776	0.025	0.713	0.187	1.000
Right whole hippocampus	3355.3 ± 397.8	3596.6 ± 305.4	3418.6 ± 356.7	2.236	0.032	0.112	0.509	0.929

MSA-CI, cognitively impaired multiple system atrophy; MSA-CP, cognitively preserved multiple system atrophy; HC, healthy control; CA, cornu ammonis; GC-ML-DG, granular cell-molecular layer-dentate gyrus; HATA, hippocampus-amygdala transition area.