Increased Use of Hyperosmolar Therapy for Suspected Clinically Apparent Brain Injury in Pediatric Patients with Diabetic Ketoacidosis during the Peak of the COVID-19 Pandemic

Table1

Incidence of suspected clinically apparent brain injury before and during the peak of the COVID-19 pandemic in pediatric patients presenting with diabetic ketoacidosis.

	Time period		Test statistic	value
	Before pandemic	During pandemic
Total
Number of episodes of DKA (n = 503)	344	159
Number of patients with suspected CABI (n = 36)	18	18
Incidence of suspected CABI (7.3%)	5.2%	11.3%	χ ^2 = 6.066	0.014
New diabetes diagnosis versus established diabetes
New
Number of episodes of DKA (n = 319)	216	103
Number of patients with suspected CABI (n = 30)	15	15
Incidence of suspected CABI (9.4%)	6.9%	14.6%	χ ^2 = 4.751	0.029
Established
Number of episodes of DKA (n = 184)	128	56
Number of patients with suspected CABI (n = 6)	3	3
Incidence of suspected CABI (3.3%)	2.3%	5.4%	Fisher’s exact test	0.371

CABI, clinically apparent brain injury; DKA, diabetic ketoacidosis.