DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk

Table 1

Characteristics of T1D cases and frequency-matched controls in the longitudinal DAISY nested case–control study.

Characteristic	Case (N = 87)	Control (N = 87)	P-value
Family history of T1D, N (%)			0.023
Affected father or sibling	49 (56.3)	31 (35.6)
Affected mother	10 (11.5)	16 (18.4)
No first-degree relative with T1D	28 (32.2)	40 (46.0)
High risk HLA-DR3/4 genotype, N (%)	42 (48.3)	17 (19.5)	6.2E-5
Male, N (%)	43 (49.4)	52 (59.8)	0.171
Non-Hispanic White, N (%)	77 (88.5)	76 (87.4)	0.816
Age at T1D diagnosis, mean years (SD)	9.7 (4.6)	n.a.