DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk
Table 2
Mediator model results of the association between family history of T1D and DNA methylation from robust linear regression adjusted for high-risk HLA DR3/4 genotype.
Probe
DMR/DMP
Near gene
Affected mother
Affected father or sibling
P-value
Estimate
Lower 95% CI
Upper 95% CI
Estimate
Lower 95% CI
Upper 95% CI
Imprinted region (DLGAP2)
cg02946697
DMR13
CTD-2281E23.1
0.24
0.12
0.36
−0.02
−0.14
0.10
1.08E-6
cg08285446
DMR13
CTD-2281E23.1
0.13
0.00
0.25
−0.01
−0.10
0.08
0.059
cg24513387
DMR13
CTD-2281E23.1
0.20
0.02
0.37
0.04
−0.09
0.18
0.098
cg25674613
DMR13
CTD-2281E23.1
0.32
0.10
0.54
0.03
−0.16
0.22
0.009
cg00565786
DMR10
CTD-2281E23.2
0.07
0.04
0.10
0.02
−0.01
0.05
8.6E-5
cg27509052
DMR10
CTD-2281E23.2
0.31
0.08
0.55
0.05
−0.14
0.25
0.026
cg19309499
DMP
CTD-2281E23.3
0.17
0.03
0.30
−0.01
−0.11
0.10
0.022
cg11192059
DMR9
DLGAP2
0.12
0.06
0.18
0.01
−0.08
0.09
1.2E-4
cg22763586
DMR9
DLGAP2
0.20
0.03
0.38
0.01
−0.12
0.15
0.046
cg27351978
DMR9
DLGAP2
0.46
0.19
0.74
0.05
−0.19
0.29
0.003
cg16922753
DMR5
ERICH1-AS1
0.32
0.05
0.58
0.07
−0.09
0.23
0.062
cg19530281
DMR5
ERICH1-AS1
0.21
0.04
0.38
0.05
−0.07
0.16
0.051
Nonimprinted region (HOPX)
cg00493422
DMR2
HOPX
0.02
−0.16
0.20
0.12
−0.02
0.25
0.166
cg04085076
DMR2
HOPX
0.02
−0.16
0.20
0.05
−0.09
0.19
0.767
cg06771126
DMR2
HOPX
0.01
−0.16
0.19
0.04
−0.10
0.19
0.809
cg16975863
DMR2
HOPX
0.03
−0.04
0.10
0.04
−0.01
0.09
0.215
cg25456368
DMR2
HOPX
0.08
−0.13
0.29
0.14
−0.04
0.32
0.304
DMR, differentially methylated region, DMR identifier Johnson et al. [13], Sci Rep. DMP, differentially methylated position.
