Splitting Mealtime Insulin Doses for Mixed Fat and Protein Meals in Children and Adolescents with Type 1 Diabetes Using Multiple Daily Injection Regimen: A Randomized Cross-Over Trial

Table 3

Comparisons between the three insulin dosing interventions used for the mixed fat and protein test meals regarding postprandial blood glucose area under the curve among the study participants.

	Intervention A; (100% ICR (lispro) ± 3-hr ISF-calculated correction dose (lispro)); (n = 43)	Intervention B; (130% ICR; 60% premeal (lispro) + 40% postmeal (lispro)); (n = 43)	Intervention C; (130% ICR; 60% premeal (lispro) + 40% postmeal (regular insulin)); (n = 43)	P1 value	P2 value	P3 value	P4 value
Total (0–6 hr) blood glucose AUC (mg × hr/dL), mean ± SD	867.91 ± 230.74	842.24 ± 261.92	774.29 ± 200.21	0.54	0.01	0.07	0.04
Early (0–3 hr) blood glucose AUC (mg × hr/dL), mean ± SD	410.84 ± 100.41	393.63 ± 113.97	379.98 ± 114.57	0.31	0.15	0.47	0.35
Late (3–6 hr) blood glucose AUC (mg × hr/dL), mean ± SD	457.43 ± 160.80	448.62 ± 171.31	394.30 ± 123.07	0.76	0.008	0.02	0.01

AUC, area under the curve, ICR, insulin-to-carbohydrate ratio; ISF, insulin sensitivity factor; SD, standard deviation. P1: p-value for comparisons between Interventions A and B. P2: p-value for comparisons between Interventions A and C. P3: p-value for comparisons between Interventions B and C. P4: p-value for comparisons between the three interventions together.