Splitting Mealtime Insulin Doses for Mixed Fat and Protein Meals in Children and Adolescents with Type 1 Diabetes Using Multiple Daily Injection Regimen: A Randomized Cross-Over Trial

Table 4

Comparisons between the three insulin dosing interventions used for the mixed fat and protein test meals regarding postprandial hypoglycemia among the study participants.

	Intervention A; (100% ICR (lispro) ± 3-hr ISF-calculated correction dose (lispro)); (n = 43)	Intervention B; (130% ICR; 60% premeal (lispro) + 40% postmeal (lispro)); (n = 43)	Intervention C; (130% ICR; 60% premeal (lispro) + 40% postmeal (regular insulin)); (n = 43)	P1 value	P2 value	P3 value	P4 value
Participants with overall postprandial hypoglycemia (BG levels < 70 mg/dL), n (%)	12 (27.9%)	12 (27.9%)	17 (39.5%)	>0.99	0.33	0.26	0.32
Participants with early postprandial hypoglycemia (BG levels < 70 mg/dL in the first 2 hr after the meal), n (%)	8 (18.6%)	9 (20.9%)	10 (23.3%)	>0.99	0.77	>0.99	0.84
Participants with postprandial BG levels < 54 mg/dL, n (%)	3 (7.0%)	2 (4.7%)	4 (9.3%)	>0.99	>0.99	0.62	0.61

BG, blood glucose; ICR, insulin-to-carbohydrate ratio; ISF, insulin sensitivity factor. P1: p-value for comparisons between Interventions A and B. P2: p-value for comparisons between Interventions A and C. P3: p-value for comparisons between Interventions B and C. P4: p-value for comparisons between the three interventions together.