Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td class="align_center" colspan="2">Characteristics</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td class="align_left"><i>n</i> = </td><td class="align_center">506</td></tr><tr><td class="align_left">Age (years) (mean ± SD)</td><td class="align_center">14.44 ± 1.99</td></tr><tr><td class="align_left">Female (%)</td><td class="align_center">64.62</td></tr><tr><td class="align_left" colspan="2">Race/ethnicity <i>n</i> (%)</td></tr><tr><td class="align_left"> Hispanic or latino</td><td class="align_center">178 (35.2)</td></tr><tr><td class="align_left"> Non-hispanic black</td><td class="align_center">185 (36.6)</td></tr><tr><td class="align_left"> Non-hispanic white</td><td class="align_center">99 (19.5)</td></tr><tr><td class="align_left"> Other</td><td class="align_center">44 (8.7)</td></tr><tr><td class="align_left">BMI <i>Z</i> score (mean ± SD)</td><td class="align_center">2.23 ± 0.46</td></tr><tr><td class="align_left">Fasting glucose (mg/dL) (mean ± SD)</td><td class="align_center">147.65 ± 52.36</td></tr><tr><td class="align_left">Fasting insulin (<i>μ</i>U/mL) (mean ± SD)</td><td class="align_center">32.91 ± 21.68</td></tr><tr><td class="align_left">HbA1c % (mean ± SD)</td><td class="align_center">6.02 ± 0.74</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Baseline demographics of TODAY participants.</div>

Pediatric Diabetes

tab1

Table 1

Table 1: Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes 