Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes

Table 2

Association of the 5 partitioned polygenic scores with baseline quantitative glycemic traits.

	β-cell		Proinsulin		Obesity		Lipodystrophy		Liver/lipid
	β	value	β	value	β	value	β	value	β	value
ln fasting glucose	0.002	0.27	0.0002	0.96	−0.003	0.23	0.003	0.27	0.001	0.7
ln fasting insulin	−0.01	0.07	−0.007	0.62	0.006	0.38	0.008	0.26	0.013	0.13
C peptide	−0.026	0.047	−0.02	0.54	0.007	0.71	0.04	0.04	0.05	0.02
Insulin sensitivity index	0.01	0.1	0.0066	0.62	−0.007	0.34	−0.009	0.24	−0.015	0.092
Insulinogenic index	−0.02	0.02	0.007	0.74	0.021	0.066	−0.004	0.76	0.01	0.5
C-peptide index	−0.013	0.08	0.0023	0.9	0.011	0.24	0.0063	0.51	0.014	0.24
Oral disposition index	−0.005	0.49	0.011	0.56	0.014	0.18	−0.001	0.94	−0.006	0.6