High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis
Table 2
Clinical characteristics and glucose metabolism data of patients with normal and abnormal glucose testing.
Normal testing for DM post AP n = 52 (73%)
Abnormal testing (pre-DM or DM) post AP n = 19 (27%)
p-value
Age at 1st AP attack (years)
14.1 (8.8–16.7) (1.5–19.5)
14.6 (8.7–17.1) (4.0–20.4)
0.75
Sex (female)
28 (54%)
11 (58%)
0.76
BMI percentile
71.4 (22.5–96.4) n = 50 (0.0–99.8)
72.9 (22.2–97.2) (3.1–98.9)
0.99
BMI ≥ 85th percentile
21/50 (42%)
8 (42%)
0.99
SAP during AP episode
7 (13%)
7 (37%)
0.04
Any positive islet cell autoantibodies at baseline or 3 months or 12 months
16 (31%)
0 (0%)
0.004
Multiple positive islet cell autoantibodies at baseline or 3 months or 12 months
4 (8%)
0 (0%)
0.57
Low C-peptide (<0.73 ng/mL)
2/20 (10%)
3/10 (30%)
0.30
Time AP to abnormal C-peptide (years)
1.1 (1.0–1.2) n = 2
0.6 (0.2–1.0) n = 3
0.40
C-peptide 3 months (ng/mL)
1.5 (1.3–2.0) n = 12
1.2 (0.7–2.0) n = 8
0.22
C-peptide 12 months (ng/mL)
1.2 (0.9–2.2) n = 13
2.8 (0.7–3.5) n = 8
0.54
Data presented as median (25th–75th percentile) (min–max) or n (%). Variables with missing data are noted with “n = ” or “/n” (denominator indicating how many had data) if not noted then full data were available. AP, acute pancreatitis; BMI, body mass index; SAP, severe acute pancreatitis; DM, diabetes mellitus. Bold values denote the statistical significance p-value.
