Markers of Myocardial Ischemia in Patients with Obstructive Sleep Apnea and Coronary Artery Disease

Table 1

Clinical characteristics.

	OSAS + CAD ()	OSAS ()	value
Demographics
Gender (female/male)	5/16	3/17	n.s.
Age (yr)	61 ± 11	54 ± 12	n.s
Body mass index (kg/m^2)	35 ± 7	33 ± 6	n.s.
Medical history
Hypertension	19 (90%)	13 (65%)	n.s.
Hypercholesterolemia	17 (81%)	5 (25%)	<0.001
Diabetes mellitus	10 (48%)	5 (25%)	n.s.
Arrhythmia	6 (29%)	1 (5%)	n.s.
Stroke	2 (10%)	0 (0%)	n.s.
Myocardial infarction	12 (57%)	0 (0%)	<0.001
COPD	4 (19%)	2 (10%)	n.s.
Medication
Nitrates	3 (14%)	0 (0%)	n.s.
-Blockers	19 (90%)	7 (35%)	<0.001
Renin inhibitor	0 (0%)	1 (5%)	n.s.
ACE inhibitors	14 (67%)	3 (15%)	<0.01
Angiotensin II receptor blockers	3 (14%)	5 (25%)	n.s.
Diuretics	11 (52%)	5 (25%)	n.s.
Calcium channel blockers	9 (43%)	5 (25%)	n.s.
-Blockers	1 (5%)	2 (10%)	n.s.
Cardiac and renal function
LVEF (%)	59 ± 9	65 ± 2	n.s.
GFR (mL/min)	121 ± 53	137 ± 43	n.s.
Polygraphy (screening)
AHI (/h)	39 ± 18	43 ± 18	n.s.
Oxygen saturation nadir (%)	70 ± 10	71 ± 8	n.s.

Data are presented as mean ± SD or No. ACE: angiotensin-converting enzyme; AHI: apnea-hypopnea-index; GFR: glomerular filtration rate; LVEF: left ventricular ejection fraction.