Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPAR
Agonists, 15-Deoxy-Delta 12, 14-Prostaglandin
Figure 3
Protective effects of
15d-PGJ2 against oxidative stress. Oxidative stress on RPE cells can
lead to intracellular accumulation of reactive oxygen species. This can result in mitochondrial dysfunction,
which in turn causes activation of the apoptosis pathway. Current data suggests that 15d-PGJ2 can block each of these events. One
mechanism that causes this protection is through upregulation of GSH synthesis
by activation of the glutamylcystein synthetase.
There is a possibility that other cytoprotective mechanisms are also
activated that lead to prevention of apoptosis.
This remains to be studied.
