PPAR𝛾, PTEN, and the Fight against Cancer

Figure 1

PTEN protein signaling pathways. PTEN’s lipid phosphatase activity dephosphorylates PIP3 to PIP2 inhibiting PDK1-mediated Akt phosphorylation and downregulating Akt-mediated cell survival. PTEN’s protein phosphatase activity inhibits the phosphorylation of FAK to prevent cell migration. PTEN’s protein phosphatase activity also dephosphorylates the SHC/SOS/GRB2 complex resulting in the decreased phosphorylation of MAPK and inhibition of the cell cycle.