WY-14643, a Potent Peroxisome Proliferator Activator Receptor-α PPAR-α Agonist Ameliorates the Inflammatory Process Associated to Experimental Periodontitis
Figure 8
Effects of WY14643 on Cleaved caspase 3 levels. We have evaluated, by western blot analysis, a key mediator of apoptosis belong to the asparate-specific cysteinyl proteases or caspases. No cleaved caspase 3 expression were detectable in the homogenized gingivomucosal tissues from the contra lateral side obtained from vehicle-treated rats (a, a1).Cleaved caspase 3 levels were appreciably increased following ligation (a, a1). Treatment of rats with WY14643 (1 mg/kg) significantly attenuated ligation-induced of Cleaved caspase 3 levels (a, a1). A representative blot of lysates (a, a1) obtained from 5 animals per group is shown and densitometry analysis of all animals is reported. Figure is representative of at least 3 experiments performed on different experimental days. versus nonligated. versus ligated.
