PPAR-𝛼 Contributes to the Anti-Inflammatory Activity of Verbascoside in a Model of Inflammatory Bowel Disease in Mice

Figure 5

Effect of endogenous PPAR-$\alpha$ on neutrophil infiltration. Myeloperoxidase (MPO) activity was significantly increased in DNBS-treated PPAR-$\alpha$WT mice in comparison to SHAM. MPO activity was significantly enhanced in DNBS-treated PPAR-$\alpha$KO mice. Treatment with VB significantly reduced the colon MPO activity. The genetic absence of the PPAR-$\alpha$ receptor significantly blocked the effect of VB treatment. Data are means $\pm$ SEM of 10 mice for each group. *$P<.01$ versus sham; °$P<.01$ versus DNBS WT.