Cardiomyocyte-Restricted Deletion of PPARβ/δ in PPARα-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation
Figure 1
Transcript levels measured by real-time RT-PCR analyses. (a) Transcript expression levels of PPARα and PPARβ/δ in CR-Pd/Pa-null and α-MyHC-Cre hearts. RNA samples were extracted from hearts of 35-week-old mice. (b) Transcript expression levels of CD36, FABP, CPT-Ib, ACADM, and MCD in α-MyHC-Cre, CR-PPARβ/δ −/−, PPARα −/−, and CR-Pd/Pa-null hearts. RNA samples were extracted from hearts of ~35-week-old mice. (c) Myocardial triglyceride content was measured in mice subjected to fasting. (d) Myocardial triglyceride content was measured in mice without fasting.
