PPAR-α Agonist Fenofibrate Upregulates Tetrahydrobiopterin Level through Increasing the Expression of Guanosine 5′-Triphosphate Cyclohydrolase-I in Human Umbilical Vein Endothelial Cells

Figure 2

Effect of fenofibrate and related compounds on ROS formation in cultured endothelial cells. DCFH-DA (20 umol/L) was added to monitor intracellular ROS production with a confocal laser scanning microscope (Leica). (a) Control group; (b) LPS group; (c) fenofibrate + LPS; (d) GW6471 + fenofibrate + LPS; (e) WY14643 + LPS; (f) statistical graph. Values are expressed as means ± SD; 𝑛=6. *𝑃<0.05; ^#𝑃<0.05 versus LPS group.

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