Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human Granulosa Cells

<table>Effects of TZDs on aromatase enzyme kinetics when testosterone was used as substrate. (a) The Lineweaver-Burk plot (reciprocal velocities of aromatase activity against reciprocal testosterone concentration) in the absence of rosiglitazone or pioglitazone. (b) The Lineweaver-Burk plot in the presence of rosiglitazone. (c) The Lineweaver-Burk plot in the presence of pioglitazone. (d) Comparison of the Lineweaver-Burk plots in the presence or absence of rosiglitazone or pioglitazone. <svg height="10.575" id="M15" style="vertical-align:-0.20064pt" version="1.1" viewbox="0 0 12.625 10.575" width="12.625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.575)">
<g transform="translate(72,-63.54)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑉</tspan>
</text>
</g>
</g>
</svg> = velocity; <svg height="10.725" id="M16" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 11.375 10.725" width="11.375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.725)">
<g transform="translate(72,-63.42)">
<text transform="matrix(1,0,0,-1,-71.95,63.6)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑆</tspan>
</text>
</g>
</g>
</svg> = substrate.</table>

PPAR Research

fig1

Figure 1

Figure 1: Rosiglitazone and Pioglitazone Alter Aromatase Kinetic Properties in Human Granulosa Cells 