Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">α</mml:mi></mml:math> Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver

<table>Histopathological changes in livers in mPPARα and hPPARα mice treated with control, high-dose DBP, DEHP, and DEHP for 2 weeks. Hepatocellular enlargements were prominently observed in mPPARα mice of DEHP group and slightly in those of DEHA and DBP. Moderate eosinophilic cytoplasm was observed in mPPARα mice treated with DEHP. Cytoplasmic vacuoles due to lipid accumulation were seen in hPPARα mice exposed to three plasticizers. Each scale bar indicates 50 μm.</table>

PPAR Research

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Figure 1

Figure 1: Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi mathvariant="bold">α</mml:mi></mml:math> Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver

Figure 1 | Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver 