AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

Table 2

Upregulated genes containing PPRE sequences^b.

	Gene ID	Gene name	Fold change
Clofibrate	None
AS601245	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	5.3
	ITGB	Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	2.9
Clofibrate +  601245	AMFR	Autocrine motility factor receptor	2.3
	ANKRD12	Ankyrin repeat domain 11	2.2
	CASP2	Caspase 2, apoptosis-related cysteine peptidase	2.7
	CBX5	Chromobox homolog 5 (HP1 alpha homolog, Drosophila)	1.4
	CCND1	Cyclin D1	1.9
	CYP1A1	Cytochrome P450, family 1, subfamily A, polypeptide 1	7.5
	DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
	DST	Dystonin	1.8
	DUSP6	Dual specificity phosphatase 6	2.2
	EHBP1	EH domain-binding protein 1	2.4
	EWSR1	Ewing sarcoma breakpoint region 1	1.8
	FOSL1	FOS-like antigen 1	1.7
	LMCD	LIM and cysteine-rich domains 1	1.8
	MARCKS	MARCKS-like 1	2.5
	MCAM	Melanoma cell adhesion molecule	1.6
	MLL3	Myeloid/lymphoid or mixed-lineage leukemia 3	2.7
	NR2F2	Nuclear receptor subfamily 2, group F, member 2	2.4
	PCYOX1	Prenylcysteine oxidase 1	1.3
	RBM8A	RNA-binding motif protein 8A	2.5
	SPEN	Spen homolog, transcriptional regulator (Drosophila)	2.2
	TBL1XR1	Transducin (beta)-like 1 X-linked receptor 1	2.5
	TTC3	Tetratricopeptide repeat domain 32	1.8
	USP47	Ubiquitin specific peptidase 47	1.7
	ZNF281	Zinc finger protein 281	1.5
	ZNF294	Ring finger protein 160	1.9

^bThe genes harbouring PPRE sequences among the upregulated genes by treatment with 5 μM clofibrate, 0.1 μM AS601245, and combined treatment versus DMSO-treated Caco-2 cells at 24 h.