PPAR Research

Research Article

Global Gene Expression Profiling in PPAR-γ Agonist-Treated Kidneys in an Orthologous Rat Model of Human Autosomal Recessive Polycystic Kidney Disease

Table 4

(a) Downregulated genes in PIO-treated compared with vehicle-treated (CONT) kidneys of PCK rats. The name of gene symbol was listed in order of PIO/CONT Log2 ratio. (b) Upregulated genes in PIO-treated compared with vehicle-treated (CONT) kidneys of PCK rats. The name of gene symbol was listed in order of PIO/CONT Log2 ratio.
(a)
Gene symbolDescriptionKEGG pathwayPIO/CONT Log 2 ratio
Olr1436Olfactory receptor 1436Olfactory transduction−3.27
Xylt1Xylosyltransferase 1Glycosaminoglycan biosynthesis-chondroitin sulfate/glycosaminoglycan biosynthesis-heparan sulfate/metabolic pathways−3.03
Map3k10Mixed-lineage kinase 2MAPK signaling pathway−2.24
Icoslg—Cell adhesion molecules (CAMs)/intestinal immune network for IgA production−2.15
Scd1Stearoyl-coenzyme A desaturase 1Biosynthesis of unsaturated fatty acids/PPAR signaling pathway−2.01
Ucp1Uncoupling protein 1PPAR signaling pathway/Huntington’s disease−1.91
OxtOxytocin, prepropeptideNeuroactive ligand-receptor interaction−1.81
Chrm1Cholinergic receptor, muscarinic 1Calcium signaling pathway/Neuroactive ligand-receptor interaction/regulation of actin cytoskeleton−1.75
AvpArginine vasopressinNeuroactive ligand-receptor interaction/vascular smooth muscle contraction/vasopressin-regulated water reabsorption−1.58
Lpcat2Lysophosphatidylcholine acyltransferase 2Glycerophospholipid metabolism/ether lipid metabolism/metabolic pathways−1.37
Il12rb1Interleukin 12 receptor, beta 1Cytokine-cytokine receptor interaction/jak-STAT signaling pathway−1.34
EDNRAEndothelin receptor type ACalcium signaling pathway/neuroactive ligand-receptor interaction/vascular smooth muscle contraction−1.30
CfdComplement factor D (adipsin)Complement and coagulation cascades−1.20
Serpinb5Serine (or cysteine) peptidase inhibitor, clade B, member 5p53 signaling pathway−1.19
Htr2b5-Hydroxytryptamine (serotonin) receptor 2BCalcium signaling pathway/neuroactive ligand-receptor interaction/gap junction−1.19
Cox8bCytochrome c oxidase, subunit VIIIbOxidative phosphorylation/metabolic pathways/cardiac muscle contraction/Alzheimer’s disease/Parkinson’s disease/Huntington’s disease−1.17
Peg12Paternally expressed 12Wnt signaling pathway−1.11
Sema3dSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3DAxon guidance−1.07
Atp1a2ATPase, Na+/K+ transporting, alpha 2 polypeptideCardiac muscle contraction/aldosterone-regulated sodium reabsorption/proximal tubule bicarbonate reclamation/salivary secretion/gastric acid secretion−1.05
Dll3Delta-like 3Notch signaling pathway−1.05
Brca2Breast cancer 2Homologous recombination/pathways in cancer/pancreatic cancer−1.04
Aqp4Aquaporin 4 (Aqp4), transcript variant 2Vasopressin-regulated water reabsorption−1.02
Gys2Glycogen synthase 2Starch and sucrose metabolism/insulin signaling pathway−1.01
KEGG pathway: Koto Encyclopedia of Gene and Genomes pathway.
(b)
Gene symbolDescriptionKEGG pathwayPIO/CONT Log 2 ratio
Gucy2dGuanylate cyclase 2d (Gucy2d)Purine metabolism/olfactory transduction/phototransduction1.59
Cyp2b1Cytochrome P450, family 2, subfamily b, polypeptide 1 (Cyp2b1), mRNAArachidonic acid metabolism/retinol metabolism/metabolism of xenobiotics by cytochrome P450/drug metabolism-cytochrome P450/metabolic pathways1.45
Cyp2d3Cytochrome P450, family 2, subfamily d, polypeptide 3 (Cyp2d3)Drug metabolism-cytochrome P4501.20
Tarsl2Threonyl-tRNA synthetase-like 2 (Tarsl2), mRNAAminoacyl-tRNA biosynthesis1.17
PrlProlactin (Prl), mRNACytokine-cytokine receptor interaction/neuroactive ligand-receptor interaction/jak-STAT signaling pathway1.17
Olr1331Olfactory receptor 1331 (Olr1331), mRNAOlfactory transduction1.17
Dync1h1Dynein cytoplasmic 1 heavy chain 1 (Dync1h1), mRNAPhagosome/vasopressin-regulated water reabsorption1.11
Olr297Olfactory receptor 297 (Olr297)Olfactory transduction1.06
KEGG pathway: Koto Encyclopedia of Gene and Genomes pathway.