PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling

Figure 1

Alteration of kidney function by clofibrate pretreatment in anti-Thy1 nephritis rat. (a) Time course of the daily urinary protein excretion in anti-Thy1 nephritis rats. ((b) and (c)) Serum concentrations of urea nitrogen and creatinine, respectively. The clofibrate-pretreatment group was fed a 0.02% or 0.1% clofibrate-containing diet from 5 days before anti-Thy1 antibody injection. The start time of the anti-Thy1 antibody injection was designated as day 0. Values represent means ± SD (𝑛=24, 12, and 24 for the Fib(−), 0.02% fibrate, and 0.1% fibrate groups, resp.). Significant differences from the respective day 0 groups are indicated with number signs ^(###𝑃<0.001), while significant differences between regular-diet and clofibrate-diet groups are indicated with asterisks (*𝑃<0.05, **𝑃<0.01, ***𝑃<0.001).

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