The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat

Figure 4

Whole body turnover and tissue specific utilization rates of glucose and FFA. Glucose and FFA flux data are shown in the left and right hand panels, respectively, under basal (open histograms) and hyperinsulinemic clamp (closed histograms) conditions. Mean ± SEM (𝑛=6-7). ^∗𝑃<0.01, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 versus Obese basal state. ^†𝑃<0.05, ^††𝑃<0.01 insulin effect in Obese versus Lean (based on Clamp-Basal differences). ^‡𝑃<0.05, ^‡‡𝑃<0.01, and ^‡‡‡𝑃<0.001 insulin effect in Tesaglitazar (Tesa) versus Obese (based on Clamp-Basal differences).