The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat

Table 1

Whole body and tissue specific fluxes of glucose and FFA.

Abbreviation	Measures	Tracer	Comment
Study 1
𝑅𝑑	Glucose disposal rate	^3H-Glucose	Best 𝑅𝑑 estimate, tracer steady-state
HGO	Hepatic glucose output	^3H-Glucose	HGO=𝑅𝑑−GIR
Study 2
𝑅𝑑^′	Glucose disposal rate index	^3H-2DG	Approx 𝑅𝑑 value, analog transient
𝑅𝑔^′	Tissue glucose utilization index	^3H-2DG
Study 3
𝑅𝑑	Glucose disposal rate	^13C-Glucose	Approx 𝑅𝑑 value, tracer transient
𝑅𝑓𝑎	FFA appearance rate	^14C-P
𝐾𝑓𝑎	FFA clearance rate	^14C-P
𝑅𝑔^′	Tissue glucose utilization index	^14C-2DG
𝑅gly	Tissue glycogen synthesis rate	^13C-Glucose
𝑅𝑓^∗	Tissue FFA utilization index	^3H-R-BrP
𝐾𝑓^∗	Tissue FFA clearance	^14C-P
𝑅𝑓𝑠	Tissue FFA storage	^14C-P