The PPARα/γ Agonist, Tesaglitazar, Improves Insulin Mediated Switching of Tissue Glucose and Free Fatty Acid Utilization In Vivo in the Obese Zucker Rat

Table 2

Body weights, plasma glucose levels and steady state clamp GIRs in Lean, Obese and Tesaglitazar groups of Zucker rats used in Study 1.

	Lean	Obese	Tesaglitazar
Body weight (g)	380±12	630±12^∗∗∗	651±18
Basal glucose (mM)	6.1±0.4	8.8±0.3^∗∗	8.7±0.9
Clamp glucose (mM)	5.5±0.3	8.6±0.4^∗∗	8.3±0.9
GIR (µmol/min/kg)	62.5±5.9	20.0±3.5^∗∗∗	80.0±5.7^†

Results are expressed as mean ± SE (𝑛 = 4-5). ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 versus Lean. ^†𝑃<0.05 versus Obese.