Neuroprotective Properties of a Novel Non-Thiazoledinedione Partial PPAR-γ Agonist against MPTP
Figure 2
LSN862 (LSN) induced neuroprotection against MPTP not upregulation of the dopaminergic phenotype. Mice were treated with MPTP or PBS and LSN doses or vehicle and euthanized 21 days later. (a) Coronal images at the level of the substantia nigra (SN) stained for Nissl. Scale bar = 100 μm. (b) Stereological cell quantification of Nissl positive SN cells (mean ± SEM; per group). ANOVA (Fisher’s LSD post hoc) # (vehicle + PBS versus vehicle + MPTP), * (vehicle + MPTP versus 30 mg/kg LSN + MPTP).
