Correlation between PPAR Gene Polymorphisms and Primary Nephrotic Syndrome in Children

Table 3

Stratified analysis of the PPAR-γ (Pro12Ala) genotypes among PNS children.

Subjects	PPAR-γ genotype		t/t′/𝜒^2/z	𝑃 value
	PP	PA/AA
Gender (male/female)	74/29	6/2	0.000	1.000
Age (years)	3.67 (0.67–13.08)	3.00 (1.50–4.25)	−1.562	0.118
BMI	17.07±0.22	17.24±0.77	−0.205	0.838
sBP (kp)	14.28±0.14	14.21±0.29	0.120	0.905
dBP (kp)	9.16±0.10	9.18±0.37	−0.046	0.963
ALB (g/L)	17.70 (11.20–37.00)	18.95 (16.80–26.30)	−1.283	0.199
BUN (mmol/L)	4.00 (0.50–16.30)	2.60 (2.20–21.50)	−1.689	0.091
Scr (μmol/L)	37.20 (18.30–207.60)	33.45 (27.60–51.50)	−1.032	0.302
UA (mmol/L)	350.76±10.96	347.88±34.60	0.071	0.943
GFR (mL/(min·1.73 m^2))	137.54±3.47	137.56±8.75	−0.002	0.999
TC (mmol/L)	9.89±0.28	9.37±0.76	0.498	0.619
TG (mmol/L)	2.46 (0.77–8.03)	2.26 (1.36–6.33)	−0.160	0.873
HDL-c (mmol/L)	1.49±0.06	1.46±0.18	0.170	0.865
Fbg (g/L)	4.58±0.16	3.37±2.26	0.536	0.686
IgA (g/L)	1.06±0.04	0.81±0.08	2.701	0.020 *
IgG (g/L)	2.26 (1.36–11.00)	2.31 (1.46–4.79)	−0.364	0.716
IgM (g/L)	1.70±0.06	1.92±0.27	−0.934	0.352
C3 (g/L)	2.49±1.22	1.28±0.06	0.279	0.781
C4 (g/L)	0.29±0.01	0.27±0.02	0.484	0.629
T (CD3+) (%)	68.95±1.09	60.00±7.11	1.700	0.093
T (CD4+) (%)	35.62±0.96	31.25±6.42	0.940	0.350
T (CD8+) (%)	27.92±0.76	21.50±3.95	1.764	0.081
NK (%)	8.00 (2.00–44.00)	5.00 (2.00–31.00)	−0.943	0.367
BC (%)	18.85±0.87	23.75±6.18	−1.156	0.251
FBG (mmol/L)	4.88±0.06	4.84±0.26	0.162	0.872
FISN (mU/L)	2.27 (0.20–16.63)	0.92 (0.20–3.17)	−2.526	0.012 *
FCP (nmol/L)	0.47 (0.18–1.95)	0.41 (0.22–0.98)	−0.981	0.327
HOMA-IR	0.48 (0.04–4.31)	0.16 (0.05–0.82)	−2.566	0.060
HOMA-islet	38.06 (−141.54–895.56)	27.06 (2.50–90.94)	−1.460	0.144
ISI	−2.46 ± 0.10	−1.46 ± 0.33	−2.777	0.006 **
24-h UP (mg/kg)	141.15 (2.96–1179.80)	117.84 (7.41–410.00)	−0.871	0.384

^∗𝑃<0.05, ^∗∗𝑃<0.01.