The Proatherogenic Effect of Chronic Nitric Oxide Synthesis Inhibition in ApoE-Null Mice Is Dependent on the Presence of PPARα

Table 2

Aortic MCP1 and RAS components mRNA levels. Each group included 7–9 animals; while there were no differences between sexes, the breakdown by gender for each group is given in parentheses. Data are given as mean ± (SE). Data are expressed relative to the level in the ApoE-null control animals; thus, the Dunnett’s posttest was chosen to follow the ANOVA.

Gene	ApoE-null; control; (4 M/4 F)	ApoE-null; L-NAME; (3 M/4 F)	DKO; control; (5 M/4 F)	DKO; L-NAME; (3 M/4 F)	P; ANOVA
MCP1	1.0 (0.05)	1.02 (0.06)	0.6* (0.08)	0.5^† (0.13)	0.001
ACE1	1.0 (0.33)	0.55 (0.09)	0.27^† (0.09)	0.23^† (0.04)	0.005
Renin	1.0 (0.51)	2.57^‡ (0.68)	2.0 (0.85)	1.68 (1.08)	NS
Angiotensinogen	1.0 (0.52)	2.25^‡ (0.53)	1.26 (0.24)	1.0 (0.52)	NS
AT1-R	1.0 (0.24)	1.79 (0.78)	1.71 (0.42)	1.59 (0.34)	NS

∗P < 0.05 versus control ApoE-null mice.
^†P < 0.01 versus control ApoE-null mice.
^‡P < 0.05 versus control ApoE-null mice by Student’s t-test.