PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

Figure 2

Overview of PPARγ activation. PPARγ typically exists as a heterodimer with RXRα, bound to corepressor molecules. Upon ligand stimulation, these corepressors are displaced and the ligand, PPARγ, RXRα, and coactivators (such as CBP and SRC1) form an active complex, binding to PPARγ response elements (PPRE). Alternatively, upon ligand stimulation PPARγ alone can bind with NF-κB to repress NF-κB target genes.