Restoration of Endothelial Function in Pparα^−/− Mice by Tempol

Figure 2

Impaired endothelium-dependent dilations in MCAs of Pparα^−/− mice. Contractile response curves to phenylephrine (PE) and dilatory response to ACh and bradykinin on PE- preconstricted middle cerebral artery (MCA) of WT and Pparα^−/− mice using isobaric myography. denotes statistical significance from WT mice (; animals). Data are means ± SEM.