Restoration of Endothelial Function in Pparα^−/− Mice by Tempol

Figure 5

Elevated superoxide levels in Pparα^−/− mice are reduced following tempol treatment. Lucigenin- (5 µM) enhanced chemiluminescence in mouse aortic segments from WT and Pparα^−/− mice after two weeks of treatment with water and tempol. Elevated levels of superoxide in Pparα^−/− mice were reduced to the level of WT mice after tempol treatment. denotes statistical significance from water treated WT mice (; animals). Data are means ± SEM.