PPAR Research

Review Article

Nutrigenomic Functions of PPARs in Obesogenic Environments

Table 3

Summary of recent publications on the effects of flavonoids: adipogenesis and PPARγ activity.
FlavonoidModelEffectPPARγ activityRef.
CatechinAdipocyte differentiation in human bone marrow mesenchymal stem cells
High-fat diet- (HFD-) induced obese SD rats		Adipogenesis ↑
Fat ↓		Activity ↑
Not measured		[5, 6]
Daidzein3T3-L1 preadipocyte differentiation
High-fat high-sucrose diet-induced obese C57BL/6J mice		Adipogenesis ↑
Adipocyte area ↓		Activity ↑
Not measured		[7]
Equol3T3-L1 preadipocyte differentiationAdipogenesis ↑Activity ↑[8]
EGCGAML-I human preadipocyte differentiationAdipogenesis ↑Not measured[9]
Fisetin3T3-L1 preadipocyte differentiationAdipogenesis ↑Activity ↑[10]
Flavanone3T3-L1 preadipocyte differentiationAdipogenesis ↑Activity ↑[11]
Hesperetin glucuronides3T3-L1 preadipocyte differentiationAdipogenesis ↓Not changed[12]
Isoflavonoids3T3-L1 preadipocyte differentiationAdipogenesis ↓Activity ↓[13]
Kaempferol3T3-L1 preadipocyte differentiationAdipogenesis ↓Activity ↑[14]
Licochalcone A3T3-L1 preadipocyte differentiation
HFD-induced obese ICR mice		Adipogenesis ↓
Body weight ↓
Plasma lipid ↓		Not measured
Not measured		 [15]
Luteolin3T3-L1 preadipocyte differentiationAdipogenesis ↓Not changed[16]
Pentamethylquercetin3T3-L1 preadipocyte differentiationAdipogenesis ↑Not measured[17]
QuercetinHFD-induced obese Wistar ratsPlasma TG ↓Not changed[18]
Quercetin-3-O-(6′′-Feruloyl)-β-D-galactopyranoside3T3-L1 preadipocyte differentiationAdipogenesis ↓Not measured[19]
Sakuranetin3T3-L1 preadipocyte differentiationAdipogenesis ↑Not changed[20]
Tangeritin3T3-L1 preadipocyte differentiationAdipogenesis ↓Not measured[21]
TG, triglyceride; HFD, high-fat diet.