Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPAR<i>γ</i> and Suppresses Adipogenesis

<div>Structural comparison of FKBP binding macrolides and timcodar. Chemical structures of FK506 (Tacrolimus), timcodar (VX-853), and rapamycin (Sirolimus). Note that VX-853 is not a macrocycle (highlighted by the presence and absence of a “macrocyclic linkage”).</div>

PPAR Research

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Figure 1

Figure 1: Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPAR<i>γ</i> and Suppresses Adipogenesis 

PPAR Research

Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis

Figure 1