PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

Table 2

Peroxisome proliferator-activated receptors (PPARs) in human skin.

Skin components	Type of PPAR expression
Epidermis and dermis
(i) Epidermal keratinocytes	PPAR-α, PPAR-β/δ, and PPAR-γ
(ii) Melanocytes	PPAR-α, PPAR-β/δ, and PPAR-γ
(iii) Fibroblasts	PPAR-γ
(iv) T lymphocytes	PPAR-α, PPAR-β/δ, and PPAR-γ
(v) Langerhan cells	PPAR-α, PPAR-β/δ, and PPAR-γ
(vi) Mast cells	PPAR-β/δ and PPAR-γ
Follicular units
(i) Hair matrix keratinocytes	PPAR-α, PPAR-β/δ, and PPAR-γ
(ii) Hair shaft cortex	PPAR-α, PPAR-β/δ, and PPAR-γ
(iii) Hair cuticle	PPAR-α, PPAR-β/δ, and PPAR-γ
(iv) Inner root sheath	PPAR-β/δ and PPAR-γ
(v) Outer root sheath	PPAR-α, PPAR-β/δ, and PPAR-γ
(vi) Dermal papilla cells	PPAR-α, PPAR-β/δ, and PPAR-γ
(vii) Connective tissue sheath	PPAR-α, PPAR-β/δ, and PPAR-γ
(viii) Sebocytes	PPAR-α, PPAR-β/δ, and PPAR-γ