Caffeoylquinic Acid-Rich Extract of Aster glehni F. Schmidt Ameliorates Nonalcoholic Fatty Liver through the Regulation of PPARδ and Adiponectin in ApoE KO Mice

Figure 10

Schematic diagram for the functional mechanism of Aster glehni extract. Amelioration of nonalcoholic fatty liver by Aster glehni is mainly accomplished with catabolic activation such as the sequential regulation of PPARδ/adiponectinP-AMPKPGC-1αSDH, also it is done by other pathway of P-AMPKP-ACC which inhibits fatty acid synthesis. Aster glehni additionally lowers triglyceride accumulation in liver by inhibiting P-ACLY, also its anti-TG accumulation effect is done through the regulation of TNFα and SOD by P-AMPK. In addition, the extract may prevent obesity via PPARδ/adiponectinP-AMPKPGC pathway. Meaning of symbols: arrow means activation, up and horizontal line means inhibition, and means blocking. Photograph of Aster glehni was quoted from Korea Rural Development Administration Genebank information center (PCV0039).