Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease

Table 1

PPARs expression and respective ligands.

Types	Major distribution	Targets
Agonist
PPARα	Liver, heart, kidney	Fenofibrate
		Clofibrate
		(FGF21)
		(G0S2)
PPARβ/δ	Skeletal muscle, liver	GW0742
		GW501516
		MBX-8025
PPARγ	Adipose tissue	TZDs
		(rosiglitazone, pioglitazone)
		Palmitate
		PGC1
PPARα/δ		GFT505 (elafibranor)
PPARα/γ		Tesaglitazar
		Glitazars (saroglitazar)
Antagonist
PPARγ		Isorhamnetin (quercetin)
PPARα/γ		Z-551